A dual-mechanism compound with antibacterial activity that targets both folate metabolism and membrane integrity, with a favourable resistance profile in vitro, is identified by screening a small molecule library.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Synergistic antibacterial effect of copper and silver nanoparticles and their mechanism of action
Scientific Reports Open Access 06 June 2023
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Wang, K. K. et al. Mol. Biol. Evol. 33, 492–500 (2016).
Martin, J. K. II et al. Cell 181, 1518–1532 (2020).
Bremner, J. B., Ambrus, J. I. & Samosorn, S. Curr. Med. Chem. 14, 1459–1477 (2007).
Jubeh, B., Breijyeh, Z. & Karaman, R. Molecules 25, 1543 (2020).
Page, M. G. P. Clin. Infect. Dis. 69 (Suppl. 7), S529–S537 (2019).
Gupta, V. & Datta, P. Indian J. Med. Res. 149, 97–106 (2019).
Liu, L. et al. Molecules 24, 1641 (2019).
Ma, Z. & Lynch, A. S. J. Med. Chem. 59, 6645–6657 (2016).
Domalaon, R., Idowu, T., Zhanel, G. G. & Schweizer, F. Clin. Microbiol. Rev. 31, e00077-17 (2018).
Parkes, A. L. & Yule, I. A. Expert Opin. Drug Discov. 11, 665–680 (2016).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Theuretzbacher, U. Dual-mechanism antibiotics. Nat Microbiol 5, 984–985 (2020). https://doi.org/10.1038/s41564-020-0767-0
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41564-020-0767-0
This article is cited by
-
A dual-targeting antifungal is effective against multidrug-resistant human fungal pathogens
Nature Microbiology (2024)
-
Unrealized targets in the discovery of antibiotics for Gram-negative bacterial infections
Nature Reviews Drug Discovery (2023)
-
Synergistic antibacterial effect of copper and silver nanoparticles and their mechanism of action
Scientific Reports (2023)