Single-molecule experiments can now quantify the surface forces that compete to package tethered DNA into a protein-rich condensate — providing much-needed mechanistic insight into the phase behaviour of the entangled genome in the nucleus.
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Feric, M. Droplets take DNA by force. Nat. Phys. 17, 981–982 (2021). https://doi.org/10.1038/s41567-021-01286-0
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DOI: https://doi.org/10.1038/s41567-021-01286-0
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Chromatin sequesters pioneer transcription factor Sox2 from exerting force on DNA
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