Effective anticancer therapies typically activate antitumour immunity, predominately mediated by T cells in the tumour microenvironment. Here, we discuss the roles of B cells and tertiary lymphoid structures in the context of chemotherapy-induced complement activation, which results in the induction of a B cell subset that modulates T cell function.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Identification and validation of eight lysosomes-related genes signatures and correlation with immune cell infiltration in lung adenocarcinoma
Cancer Cell International Open Access 13 December 2023
-
Clinical relevance of tertiary lymphoid structures in esophageal squamous cell carcinoma
BMC Cancer Open Access 24 June 2022
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Fridman, W. H., Zitvogel, L., Sautès–Fridman, C. & Kroemer, G. The immune contexture in cancer prognosis and treatment. Nat. Rev. Clin. Oncol. 14, 717–734 (2017).
Lu, Y. et al. Complement signals determine opposite effects of b cells in chemotherapy-induced immunity. Cell 180, 1081–1097 (2020).
Roumenina, L. T., Daugan, M. V., Petitprez, F., Sautès-Fridman, C. & Fridman, W. H. Context-dependent roles of complement in cancer. Nat. Rev. Cancer 19, 698–715 (2019).
Wouters, M. C. & Nelson, B. H. Prognostic significance of tumor-infiltrating B cells and plasma cells in human cancer. Clin. Cancer Res. 24, 6125–6135 (2018).
Sautès-Fridman, C., Petitprez, F., Calderaro, J. & Fridman, W. H. Tertiary lymphoid structures in the era of cancer immunotherapy. Nat. Rev. Cancer 19, 307–325 (2019).
Kranich, J. & Krautler, N. J. How follicular dendritic cells shape the B cell antigenome. Front Immunol. 7, 225 (2016).
Ma, C. S. et al. Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies. J. Allergy Clin. Immunol. 136, 993–1006 (2015).
Petitprez, F. et al. B cells are associated with survival and immunotherapy response in sarcoma. Nature 577, 556–560 (2020).
Helmink, B. A. et al. B cells and tertiary lymphoid structures promote immunotherapy response. Nature 577, 549–555 (2020).
Cabrita, R. et al. Tertiary lymphoid structures improve immunotherapy and survival in melanoma. Nature 577, 561–565 (2020).
Acknowledgements
We wish to thank Wolf H. Fridman for discussions about this topic and his review of this manuscript.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Sautès-Fridman, C., Roumenina, L.T. B cells and complement at the forefront of chemotherapy. Nat Rev Clin Oncol 17, 393–394 (2020). https://doi.org/10.1038/s41571-020-0376-0
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41571-020-0376-0
This article is cited by
-
Identification and validation of eight lysosomes-related genes signatures and correlation with immune cell infiltration in lung adenocarcinoma
Cancer Cell International (2023)
-
Novel prognostic implications of complement activation in the tumour microenvironment for de novo metastatic BRAF V600E mutant colorectal cancer
British Journal of Cancer (2023)
-
Clinical relevance of tertiary lymphoid structures in esophageal squamous cell carcinoma
BMC Cancer (2022)