Available interventions for adolescents with obesity are based on behavioural therapy and lifestyle modification. A new randomized, controlled trial provides evidence of efficacy of a pharmacological therapy, liraglutide, for weight control in adolescent obesity. The indications for more widespread use of this medication in clinical practice are under discussion.
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References
NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128.9 million children, adolescents, and adults. Lancet 390, 2627–2642 (2017).
Kelishadi, R. et al. Controlling childhood obesity: A systematic review on strategies and challenges. J. Res. Med. Sci. 19, 993–1008 (2014).
Bahia, L. et al. Overview of meta-analysis on prevention and treatment of childhood obesity. J. Pediatr. 95, 385–400 (2019).
Srivastava, G. et al. Clinical considerations regarding the use of obesity pharmacotherapy in adolescents with obesity. Obesity (Silver Spring) 27, 190–204 (2019).
Anderson, K. L. A review of the prevention and medical management of childhood obesity. Child Adolesc. Psychiatr. Clin. N. Am. 27, 63–76 (2018).
Lentferink, Y. E. et al. Efficacy of metformin treatment with respect to weight reduction in children and adults with obesity: a systematic review. Drugs 78, 1887–1901 (2018).
Lin, C. H. et al. An evaluation of liraglutide including its efficacy and safety for the treatment of obesity. Expert Opin. Pharmacother. 21, 275–285 (2020).
Tamborlane, W. V. et al. Liraglutide in children and adolescents with type 2 diabetes. N. Engl. J. Med. 381, 637–646 (2019).
Kelly, A. S. et al. A randomized, controlled trial of liraglutide for adolescents with obesity. N. Engl. J. Med. https://doi.org/10.1056/NEJMoa1916038 (2020).
Martinez, S. M. et al. Mechanisms linking childhood weight status to metabolic risk in adolescence. Pediatr. Diabetes 21, 203–209 (2020).
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Kelishadi, R. Liraglutide for management of adolescent obesity. Nat Rev Endocrinol 16, 405–406 (2020). https://doi.org/10.1038/s41574-020-0371-7
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DOI: https://doi.org/10.1038/s41574-020-0371-7
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