Table 1 Association between HLA alleles and MS in UK Biobank and IMSGC cohort
From: The UK Biobank resource with deep phenotyping and genomic data
HLA allele | Test | UK Biobank | IMSGC | ||
---|---|---|---|---|---|
OR (95% CI) | P value | OR (95% CI) | P value | ||
HLA-DRB1*15:01 | Additive effect | 3.16 (2.81–3.54) | 2.58 × 10−85 | 3.92 (3.74–4.12) | <1 × 10−600 |
Homozygote correction | 0.67 (0.52–0.87) | 2.32 × 10−3 | 0.54 (0.47–0.61) | 8.50 × 10−22 | |
HLA-A*02:01 | Additive effect | 0.69 (0.62–0.78) | 2.30 × 10−10 | 0.67 (0.64–0.70) | 7.80 × 10−70 |
Homozygote correction | 1.20 (0.89–1.62) | 2.41 × 10−1 | 1.26 (1.13–1.41) | 3.30 × 10−05 | |
HLA-DRB1*03:01 | Additive effect | 1.21 (1.06–1.37) | 3.39 × 10−3 | 1.16 (1.10–1.22) | 3.50 × 10−08 |
Homozygote correction | 2.12 (1.53–2.94) | 6.84 × 10−6 | 2.58 (2.19–3.03) | 1.30 × 10−30 | |
HLA-DRB1*13:03 | Additive effect | 2.10 (1.54–2.85) | 2.36 × 10−6 | 2.62 (2.32–2.96) | 6.20 × 10−55 |
HLA-DRB1*08:01 | Additive effect | 1.56 (1.21–2.01) | 6.13 × 10−4 | 1.55 (1.42–1.69) | 1.00 × 10−23 |
HLA-B*44:02 | Additive effect | 0.86 (0.74–0.98) | 2.94 × 10−2 | 0.78 (0.74–0.83) | 4.70 × 10−17 |
HLA-B*38:01 | Additive effect | 0.29 (0.13–0.65) | 2.55 × 10−3 | 0.48 (0.42–0.56) | 8.00 × 10−23 |
HLA-B*55:01 | Additive effect | 0.99 (0.75–1.31) | 9.47 × 10−1 | 0.63 (0.55–0.73) | 6.90 × 10−11 |
HLA-DQA1*01:01 | Additive effect in the presence of HLA-DRB1*15:01 | 0.71 (0.56–0.90) | 5.33 × 10−3 | 0.65 (0.59–0.72) | 1.30 × 10−17 |
HLA-DQB1*03:02 | Dominant effect | 1.07 (0.92–1.25) | 3.71 × 10−1 | 1.30 (1.23–1.37) | 1.80 × 10−22 |
HLA-DQB1*03:01 | Allelic interaction with HLA-DQB1*03:02 | 0.8 (0.53–1.20) | 2.81 × 10−1 | 0.60 (0.52–0.69) | 7.10 × 10−12 |