Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

PROTEIN THERAPY

Precision cancer targeting with antibody pairs

Logic-gated monoclonal antibodies have been designed to improve safety and efficacy.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: HexElect technology.

References

  1. Christian, B. A. & Lin, T. S. Semin. Hematol. 45, 95–103 (2008).

    Article  CAS  Google Scholar 

  2. Alinari, L. et al. Oncogene 26, 3644–3653 (2007).

    Article  CAS  Google Scholar 

  3. Oostindie, S. C. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-022-01384-1 (2022).

    Article  PubMed  Google Scholar 

  4. Lajoie, M. J. et al. Science 369, 1637–1643 (2020).

    Article  CAS  Google Scholar 

  5. Roybal, K. T. et al. Cell 164, 770–779 (2016).

    Article  CAS  Google Scholar 

  6. Banaszek, A. et al. Nat. Commun. 10, 5387 (2019).

    Article  Google Scholar 

  7. Diebolder, C. A. et al. Science 343, 1260–1263 (2014).

    Article  CAS  Google Scholar 

  8. Oostindie, S. C. et al. Haematologica 104, 1841–1852 (2019).

    Article  CAS  Google Scholar 

  9. Macor, P., Capolla, S. & Tedesco, F. Front. Immunol. 9, 2203 (2018).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Robert T. Lawrence or Peter D. Senter.

Ethics declarations

Competing interests

The authors are employed by Seagen, Inc.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lawrence, R.T., Senter, P.D. Precision cancer targeting with antibody pairs. Nat Biotechnol 40, 1434–1435 (2022). https://doi.org/10.1038/s41587-022-01401-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41587-022-01401-3

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing