Supplementary Figure 1: MAGOH and MAGOHB score as reciprocal paralog dependencies in both genome-scale CRISPR and shRNA screening datasets. | Nature Genetics

Supplementary Figure 1: MAGOH and MAGOHB score as reciprocal paralog dependencies in both genome-scale CRISPR and shRNA screening datasets.

From: Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer

Supplementary Figure 1

a, Plot of the percentage DNA sequence identity between gene pairs versus Pearson correlation for their co-expression across the CCLE cell lines (n = 93,433 gene pairs plotted). The solid line shows the mean; the shaded region shows the standard error. b, Correlation between MAOGHB expression (y axis) and MAGOH dependency in CRISPR data (x axis). Pearson’s r2 = 0.2235 (n = 336 cell lines plotted). c, Correlation between MAGOH gene dependencies in shRNA (y axis) and CRISPR (x axis) data. Pearson’s r2 = 0.1763 (n = 215 cell lines plotted). d, Correlation between MAGOH expression (y axis) and MAGOHB dependency in CRISPR data (x axis). Pearson’s r2 = 0.1113 (n = 336 cell lines plotted). e, Correlation between MAGOHB gene dependencies in shRNA (y axis) and CRISPR (x axis) data. Pearson’s r2 = 0.3068 (n = 215 cell lines plotted).

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