Supplementary Figure 6: The AluJb TE is methylated in somatic tissue and is epigenetically dysregulated in lung cancer cell lines.
From: Transposable elements drive widespread expression of oncogenes in human cancers
a, DNA methylome profiles of multiple somatic tissues from the Roadmap Epigenomics Project (http://www.roadmapepigenomics.org/) are displayed on the WashU Epigenome Browser (http://epigenomegateway.wustl.edu/browser/). b, Schematics showing DNA methylation levels of AluJb in different cancer cell lines. An alternative start codon present in AluJb generates a chimeric LIN28B peptide that lacks 3 amino acids contributed by exon 1, but has 22 novel amino acids prepended. c, Predicted amino acid sequence of AluJb-LIN28B protein. d, Cropped Western blot (repeated twice with similar results) representing the size difference between the AluJb-LIN28B protein and canonical LIN28B protein.
