The Cardiometabolic Disorders in African-Ancestry Populations (CARDINAL) study site is a well-powered, first-of-its-kind resource for developing, refining and validating methods for research into polygenic risk scores that accounts for local ancestry, to improve risk prediction in diverse populations.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Polygenic risk scores for disease risk prediction in Africa: current challenges and future directions
Genome Medicine Open Access 30 October 2023
-
Generalisation of genomic findings and applications of polygenic risk scores
BMC Medical Genomics Open Access 28 July 2023
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Diseases, G. B. D. & Injuries, C. Lancet 396, 1204–1222 (2020).
Adebamowo, S. N., Tekola-Ayele, F., Adeyemo, A. A. & Rotimi, C. N. Public Health Genomics 20, 9–26 (2017).
Dikilitas, O. et al. Am. J. Hum. Genet. 106, 707–716 (2020).
Wuttke, M. et al. Nat. Genet. 51, 957–972 (2019).
Levy, D. et al. Nat. Genet. 41, 677–687 (2009).
Hu, Y. et al. Stroke 53, 875–885 (2022).
Popejoy, A. B. & Fullerton, S. M. Nature 538, 161–164 (2016).
Mogil, L. S. et al. PLoS Genet. 14, e1007586 (2018).
Vilhjalmsson, B. J. et al. Am. J. Hum. Genet. 97, 576–592 (2015).
Schizophrenia Working Group of the Psychiatric Genomics. Nature 511, 421–427 (2014).
Belsky, D. W. et al. Biodemogr. Soc. Biol. 59, 85–100 (2013).
Akiyama, M. et al. Nat. Genet. 49, 1458–1467 (2017).
Lee, J. J. et al. Nat. Genet. 50, 1112–1121 (2018).
Martin, A. R. et al. Nat. Genet. 51, 584–591 (2019).
Buniello, A. et al. Nucleic Acids Res. 47, D1005–D1012 (2019).
Morales, J. et al. Genome Biol. 19, 21 (2018).
Hindorff, L. A. et al. Nat. Rev. Genet. 19, 175–185 (2018).
Choudhury, A. et al. Nature 586, 741–748 (2020).
Lazaridis, I. et al. Nature 536, 419–424 (2016).
Khera, A. V. et al. N. Engl. J. Med. 375, 2349–2358 (2016).
Prive, F. et al. Am. J. Hum. Genet. 109, 12–23 (2022).
Kanai, M. et al. Nat. Genet. 50, 390–400 (2018).
Ofori-Acquah, S. F. & The SickleGenAfrica Network. Lancet Glob Health 8, e1255–e1256 (2020).
Marnetto, D. et al. Nat. Commun. 11, 628 (2020).
Choi, S. W., Mak, T. S. & O’Reilly, P. F. Nat. Protoc. 15, 2759–2772 (2020).
Acknowledgements
CARDINAL is funded by the Polygenic Risk Score (PRS) Methods and Analysis for Populations of Diverse Ancestry – Study Sites (NIH/NHGRI 1U01HG011717). We are very grateful to the individuals who participated in the studies included in the CARDINAL study site and members of the research groups that contributed to each study. We are also grateful for the following projects funded by the National Institutes of Health (NIH): African Collaborative Center for Microbiome and Genomics Research Grant (NIH/NHGRI 1U54HG006947), AWI-Gen Collaborative Centre (NIH/NHGRI U54HG006938); Eyes of Africa: The Genetics of Blindness (NIH/NHGRI and NEI, U54HG009826); and SIREN (U54HG007479). T.C. is an international training fellow supported by the Wellcome Trust grant (214205/Z/18/Z). S.F. is an international Intermediate Fellow funded by the Wellcome Trust grant (220740/Z/20/Z) at the MRC/UVRI and LSHTM
Author information
Authors and Affiliations
Contributions
S.N.A. drafted the manuscript, created the figures and tables. All authors reviewed the manuscript and approved the final version.
Corresponding author
Ethics declarations
Competing interests
The authors declare no conflict of interest. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscripts.
Rights and permissions
About this article
Cite this article
Adebamowo, C.A., Adeyemo, A., Ashaye, A. et al. Polygenic risk scores for CARDINAL study. Nat Genet 54, 527–530 (2022). https://doi.org/10.1038/s41588-022-01074-3
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41588-022-01074-3
This article is cited by
-
Generalisation of genomic findings and applications of polygenic risk scores
BMC Medical Genomics (2023)
-
Polygenic risk scores for disease risk prediction in Africa: current challenges and future directions
Genome Medicine (2023)