The proteome-wide application of a probe that selectively labels cysteine residues oxidized to the sulfinic acid form reveals the mammalian S-sulfinylome and uncovers novel substrates of the sulfinyl reductase sulfiredoxin, opening yet unexplored realms of cysteine-based redox regulation.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Yang, K. S. et al. J. Biol. Chem. 277, 38029–38036 (2002).
Biteau, B., Labarre, J. & Toledano, M. B. Nature 425, 980–984 (2003).
Akter, S. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-018-0116-2 (2018).
Laurent, T. C., Moore, E. C. & Reichard, P. J. Biol. Chem. 239, 3436–3444 (1964).
Zheng, M., Aslund, F. & Storz, G. Science 279, 1718–1721 (1998).
Stamler, J. S. et al. Proc. Natl. Acad. Sci. USA 89, 444–448 (1992).
Sundaresan, M., Yu, Z. X., Ferrans, V. J., Irani, K. & Finkel, T. Science 270, 296–299 (1995).
D’Autréaux, B. & Toledano, M. B. Nat. Rev. Mol. Cell Biol. 8, 813–824 (2007).
Wood, Z. A., Poole, L. B. & Karplus, P. A. Science 300, 650–653 (2003).
Jeong, W., Bae, S. H., Toledano, M. B. & Rhee, S. G. Free Radic. Biol. Med. 53, 447–456 (2012).
Hanzén, S. et al. Cell 166, 140–151 (2016).
Roussel, X. et al. J. Biol. Chem. 283, 22371–22382 (2008).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Rahuel-Clermont, S., Toledano, M.B. Parsing protein sulfinic acid switches. Nat Chem Biol 14, 991–993 (2018). https://doi.org/10.1038/s41589-018-0151-z
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41589-018-0151-z