NLRP3-driven sterile inflammation facilitates the pathogenesis of various human inflammatory diseases. New work identifies apolipoprotein C3 as an endogenous NLRP3 agonist that promotes sterile inflammation and organ damage.
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Gong, T., Zhou, R. ApoC3: an ‘alarmin’ triggering sterile inflammation. Nat Immunol 21, 9–11 (2020). https://doi.org/10.1038/s41590-019-0562-3
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DOI: https://doi.org/10.1038/s41590-019-0562-3
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