IL-33 is shown to play a cell-intrinsic role in maintenance of the functional identity of regulatory T cells in the tumor microenvironment. Genetic inhibition of IL-33 potentiates the therapeutic effect of checkpoint inhibitor immunotherapy in a melanoma mouse tumor model.
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References
Togashi, Y., Shitara, K. & Nishikawa, H. Nat. Rev. Clin. Oncol. 16, 356–371 (2019).
Alissafi, T., Hatzioannou, A., Legaki, A. I., Varveri, A. & Verginis, P. J. Autoimmun 104, 102310 (2019).
Hatzioannou, A. et al. Nat. Immunol. https://doi.org/10.1038/s41590-019-0555-2 (2019).
Larsen, K. M., Minaya, M. K., Vaish, V. & Pena, M. M. O. Int. J. Mol. Sci. 19, E2676 (2018).
Toker, A. et al. J. Immunol. 190, 3180–3188 (2013).
Overacre-Delgoffe, A. E. & Vignali, D. A. A. Cancer Immunol. Res. 6, 882–887 (2018).
Zeng, H. & Chi, H. Curr. Opin. Immunol. 46, 103–111 (2017).
Ali, S. et al. J. Immunol. 187, 1609–1616 (2011).
Overacre-Delgoffe, A. E. et al. Cell 169, 1130–1141.e1111 (2017).
Di Pilato, M. et al. Nature 570, 112–116 (2019).
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Demeyer, A., Beyaert, R. Fragility can be a good thing in cancer. Nat Immunol 21, 11–13 (2020). https://doi.org/10.1038/s41590-019-0564-1
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DOI: https://doi.org/10.1038/s41590-019-0564-1
