Whether and how thymic tolerance to tissue-restricted antigens (TRA) could be achieved posed a conundrum until Klein and colleagues discovered that medullary thymic epithelial cells were capable of bursts of TRA expression.
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Acknowledgements
This article is dedicated to the memory of Bruno Kyewski. I thank all the members of my team who have worked with me over the years and apologize to those who embarked on projects that actually got less exciting when things stopped falling into place.
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Klein, L. Recollections of the discovery of promiscuous antigen expression in mTECs. Nat Immunol 21, 1303–1305 (2020). https://doi.org/10.1038/s41590-020-0771-9
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DOI: https://doi.org/10.1038/s41590-020-0771-9
