New research demonstrates that γδ T cells recognize Plasmodium-infected erythrocytes via interaction of the T cell antigen receptor with the phosphoantigen sensor BTN3A1 and subsequently destroy infected cells through either cytotoxic molecule secretion or antibody-dependent phagocytosis.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Crutcher, J. M. & Hoffman, S. L. in Medical Microbiology 4th edn (ed. Baron, S.) Ch. 83 (The University of Texas Medical Branch at Galveston, 1996).
Crompton, P. D. et al. Annu. Rev. Immunol. 32, 157–187 (2014).
Long, C. A. & Zavala, F. Cold Spring Harb. Perspect. Med. 7, a025577 (2017).
World Health Organization. World Malaria Report 2018 (World Health Organization, 2018).
Junqueira, C. et al. Nat. Immunol. https://doi.org/10.1038/s41590-020-00847-4 (2021).
Lawand, M., Déchanet-Merville, J. & Dieu-Nosjean, M.-C. Front. Immunol. 8, 761 (2017).
Farrington, L. A. et al. J. Infect. Dis. 213, 1483–1490 (2016).
Zaidi, I. et al. J. Immunol. 199, 3781–3788 (2017).
Ishizuka, A. S. et al. Nat. Med. 22, 614–623 (2016).
Costa, G. et al. Blood 118, 6952–6962 (2011).
Guenot, M. et al. Infect. Immun. 83, 3816–3824 (2015).
Hernández-Castañeda, M. A. et al. J. Immunol. 204, 1798–1809 (2020).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Lefebvre, M.N., Harty, J.T. γδ T cells burst malaria’s bubble. Nat Immunol 22, 270–272 (2021). https://doi.org/10.1038/s41590-021-00879-4
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41590-021-00879-4