Intra-islet CD8+ T cells from a mouse model of type 1 diabetes exhibit an exhausted phenotype that differs from the canonical T cell exhaustion observed in cancer and chronic viral infection. Deletion of the inhibitory receptor LAG3 in these cells accelerated diabetes incidence and partially reversed this restrained phenotype.
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References
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This is a summary of: Grebinoski, S. et al. Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3. Nat. Immunol. https://doi.org/10.1038/s41590-022-01210-5 (2022).
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Defining an exhaustion-like program that restrains autoreactive CD8+ T cells. Nat Immunol 23, 832–833 (2022). https://doi.org/10.1038/s41590-022-01211-4
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DOI: https://doi.org/10.1038/s41590-022-01211-4