m1A58 is a common tRNA modification that can influence protein translational efficiency. Here Liu et al. reveal that tRNA methylation controls in vivo T cell activation by enhancing translation of the key transcription factor Myc.
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Marchingo, J.M. tRNA methylation — a new level of control for T cell immunity. Nat Immunol 23, 1401–1402 (2022). https://doi.org/10.1038/s41590-022-01317-9
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DOI: https://doi.org/10.1038/s41590-022-01317-9
