CD40 has long been known as a co-stimulatory molecule involved in T cell help for dendritic cells, and thereby as a contributor to CD8+ T cell immunity against cancers and infections. However, CD40 signaling drives complex functional responses that can contribute to tumor-specific CD8+ T cell responses in unexpected ways.
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References
Ardouin, L. et al. Immunity 45, 305–318 (2016).
Bedoui, S. et al. Immunol. Rev. 272, 52–64 (2016).
Wu, R. et al. Nat. Immunol. https://doi.org/10.1038/s41590-022-01324-w (2022).
Ferris, S. T. et al. Nature 584, 624–629 (2020).
Ahrends, T. et al. Immunity 47, 848–861 (2017).
Bevan, M. J. Nat. Rev. Immunol. 4, 595–602 (2004).
Roberts, E. W. et al. Cancer Cell 30, 324–336 (2016).
Busselaar, J. et al. Front. Immunol. 11, 592569 (2020).
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Bedoui, S., Gebhardt, T. Unappreciated complexity in T cell help for dendritic cells. Nat Immunol 23, 1515–1516 (2022). https://doi.org/10.1038/s41590-022-01335-7
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DOI: https://doi.org/10.1038/s41590-022-01335-7
