Sepsis is a global health issue in great need of effective therapies. Analysis of gene expression profiles in different tissues and at the whole-body level in mice enabled the characterization of the organism-wide host response to sepsis, which will help to build a unified mechanistic framework for the disease.
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This is a summary of: Takahama, M. et al. A pairwise cytokine code explains the organism-wide response to sepsis. Nat. Immunol. https://doi.org/10.1038/s41590-023-01722-8 (2024).
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Three cytokine pairs modulate sepsis effects at the organism level. Nat Immunol 25, 202–203 (2024). https://doi.org/10.1038/s41590-024-01742-y
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DOI: https://doi.org/10.1038/s41590-024-01742-y