The human heart contains two macrophage populations with distinct self-maintenance and inflammatory functions. A shift in the balance between these macrophage populations correlates with left-ventricle remodeling and systolic function in patients with heart failure.
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References
Ginhoux, F. & Guilliams, M. Immunity 44, 439–449 (2016).
Epelman, S. et al. Immunity 40, 91–104 (2014).
Molawi, K. et al. J. Exp. Med. 211, 2151–2158 (2014).
Van der Borght, K. & Lambrecht, B. N. Cell. Immunol. https://doi.org/10.1016/j.cellimm.2018.03.011 (2018).
Sawai, C. M. et al. Immunity 45, 597–609 (2016).
Bajpai, G. et al. Nat. Med. https://doi.org/10.1038/s41591-018-0059-x (2018).
McGovern, N. et al. Immunity 41, 465–477 (2014).
Nayak, D. K. et al. Am. J. Transplant. 16, 2300–2311 (2016).
Guilliams, M. & Scott, C. L. Nat. Rev. Immunol. 17, 451–460 (2017).
Bonnardel, J. & Guilliams, M. Curr. Opin. Immunol. 50, 64–74 (2018).
Rozenblatt-Rosen, O., Stubbington, M. J. T., Regev, A. & Teichmann, S. A. Nature 550, 451–453 (2017).
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Svedberg, F.R., Guilliams, M. Cellular origin of human cardiac macrophage populations. Nat Med 24, 1091–1092 (2018). https://doi.org/10.1038/s41591-018-0143-2
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DOI: https://doi.org/10.1038/s41591-018-0143-2
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