Extended Data Fig. 9: Evidence of latent EBV infection at the site of encephalitic inflammation. | Nature Medicine

Extended Data Fig. 9: Evidence of latent EBV infection at the site of encephalitic inflammation.

From: A case report of clonal EBV-like memory CD4+ T cell activation in fatal checkpoint inhibitor-induced encephalitis

Extended Data Fig. 9

a,b, EBER(1/2) staining of lymphocytes by RNA in situ hybridization in the cortex and meninges (a) and of the encephalitic infarct (b). c,d, EBNA1 staining of lymphocytes by RNA in situ hybridization in the cortex and meninges (c) and of the encephalitic infarct (d). e, Positive EBER staining of rare lymphocytes in lymph node resection pre-dating anti-PD-1 therapy, suggesting historic EBV infection. f, Positive EBER staining of rare tumor cells in brain metastasis resection predating anti-PD-1 therapy, also suggesting historic EBV infection. Stains were performed on a single tissue section with a batch-controlled positive and negative control.

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