New structural work sheds light on the architecture of otopetrin channels, offering insights into the mechanisms for proton permeation in this family.
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The roles of two extracellular loops in proton sensing and permeation in human Otop1 proton channel
Communications Biology Open Access 20 October 2022
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Supported by grants from the Gustafsson Foundation and Science for Life Laboratory.
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Delemotte, L. Outlining the proton-conduction pathway in otopetrin channels. Nat Struct Mol Biol 26, 528–530 (2019). https://doi.org/10.1038/s41594-019-0260-8
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DOI: https://doi.org/10.1038/s41594-019-0260-8
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The roles of two extracellular loops in proton sensing and permeation in human Otop1 proton channel
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