Table 1 List of representative dysregulated genes between APFL and AP.

RT1-A3

Uncharacterized protein

18.07504

Positive regulation of T cell mediated cytotoxicity

Yes (1.32E-05)

MSC

Musculin

12.34538

Negative regulation of transcription from RNA polymerase II promoter

Yes (9.45E-04)

FBXO27

F-box protein 27

11.24744

Glycoprotein binding

Yes (1.76E-07)

MSX1

Msh homeobox 1

10.72489

Negative regulation of cell growth

Yes (3.39E-04)

RGD1561212

Similar to RIKEN cDNA

10.69475

Exhibits retinoic acid receptor binding

Yes (1.46E-07)

SIGLEC8

Sialic acid binding Ig-like lectin 8

9.65489

Intracellular signal transduction

Yes (2.15E-05)

RAMP3

Receptor (G protein-coupled) activity modifying protein 3

9.49772

Regulation of G-protein coupled receptor protein signaling pathway

Yes (3.41E-18)

ZFYVE28

Zinc finger, FYVE domain containing 28

9.45763

Negative regulation of epidermal growth factor

Yes (7.88E-09)

TNFAIP6

Tumor necrosis factor alpha induced protein 6

9.33946

Negative regulation of inflammatory response

Yes (1.36E-06)

AOC1

Amine oxidase, copper containing 1

9.18586

Amine metabolic process

Yes (1.03E-04)

TNN

Tenascin N

8.82202

Cell-matrix adhesion

Yes (4.54E-07)

PTX3

Pentraxin 3

8.80702

Innate immune response

Yes (1.73E-06)

LMX1A

LIM homeobox transcription factor 1 alpha

8.36729

Regulation of transcription, DNA-templated

Yes (1.65E-04)

RASEF

RAS and EF hand domain containing

7.90165

Rab protein signal transduction

Yes (1.77E-04)

LOC497963

Similar to Nitric oxide synthase

7.78913

Nitric oxide biosynthetic process

Yes (2.15E-03)

DGKH

Diacylglycerol kinase

7.55722

Protein oligomerization

Yes (4.43E-06)

SLC7AL1

Solute carrier family 7, member 11

7.18928

Response to oxidative stress

Yes (7.32E-06)

DNM3

Dynamin 3

5.22016

Anatomical structure development

Yes (1.46E-07)

LRRC8E

Leucine rich repeat containing 8 family

5.07676

Ion transport

Yes (2.36E-06)

VWA2

Von Willebrand factor A domain containing 2

4.13783

Regulation of insulin receptor signaling pathway

Yes (2.53 E-03)

EGR2

Early growth response 2

4.11453

Cellular protein modification process

Yes (5.49 E-06)

FOSL2

Fos-like antigen 2

4.03226

Positive regulation of fibroblast proliferation

Yes (1.49 E-03)

TREM1

Triggering receptor expressed on myeloid cells 1

3.94884

Neutrophil chemotaxis

Yes (3.92 E-03)

FOSL1

Fos-like antigen 1

3.30191

Neurological system process

Yes (1.80 E-05)

GAS1

Growth arrest-specific 1

2.79755

Negative regulation of mitotic cell cycle

Yes (1.10E-20)

WDR4

WD repeat domain 4

1.30914

tRNA methylation

Yes (8.61E-03)

PTPRM

Protein tyrosine phosphatase, receptor type, M

−1.0036

Peptidyl-tyrosine dephosphorylation

Yes (1.55 E-04)

CDKN1C

CDKI protein long isoform

−1.71620

Cell cycle arrest

Yes (6.87 E-03)

UBD

Ubiquitin D

−2.32347

Protein ubiquitination

Yes (2.83E-06)

RGMA

Repulsive guidance molecule family member A

−2.87523

Negative regulation of collateral sprouting

Yes (8.81E-19)

BRDT

Bromodomain, testis-specific

−2.90388

Chromatin remodeling

Yes (4.13 E-03)

CD8A

CD8a molecule

−3.37913

Response to stress

Yes (6.91E-06)

FOXH1

Forkhead box H1

−3.95036

Anatomical structure development

Yes (9.49E-23)

PDE3A

Phosphodiesterase 3A

−4.67631

Small molecule metabolic process

Yes (4.37E-06)

TFF3

Tff3 molecule

−4.82677

Regulation of glucose metabolic process

Yes (5.44E-04)

OTOGL

Otogelin-like

−6.85145

Sensory perception of sound

Yes (6.46 E-04)

NPR3

Natriuretic peptide receptor 3

−8.79741

Negative regulation of adenylate cyclase activity

Yes (1.81E-03)

LOC100360055

Cytochrome P450 2B15-like

−9.82802

Xenobiotic metabolic process

Yes (8.93E-05)

MMD2

Monocyte to macrophage differentiation -associated 2

−10.26003

Protein phosphorylation

Yes (2.30E-08)

CML3

Camello-like 3

−10.90368

Gastrulation with mouth forming second

Yes (1.13E-13)

ALDH1A7

Aldehyde dehydrogenase family 1

−13.13943

Oxidation-reduction process

Yes (3.74E-28)