Table 2 Meropenem susceptibilities (mg/L) for 48 Klebsiella isolates from diverse locations and with diverse resistance mechanisms.

From: Rapid susceptibility profiling of carbapenem-resistant Klebsiella pneumoniae

Isolate

Origin

Mechanism

Referring Lab’s MIC

MICBMD

MICFAST

BMD S/NS

FAST S/NS

2440606

England

 

≤0.06

≤0.25

≤0.25

S

S

2880622

England

 

≤0.06

≤0.25

≤0.25

S

S

51575

Sweden

ESBL

0.064

≤0.25

≤0.25

S

S

515870

Sweden

ESBL

0.125

≤0.25

≤0.25

S

S

ATCC 700603

USA

 

≤0.25

≤0.25

≤0.25

S

S

ATCC BAA 1706

USA

 

≤0.25

≤0.25

≤0.25

S

S

3354

Australia

 

≤0.25

≤0.25

0.5

S

S

18397

Australia

 

≤0.25

≤0.25

≤0.25

S

S

43288

Australia

 

≤0.25

≤0.25

≤0.25

S

S

43292

Australia

 

≤0.25

≤0.25

≤0.25

S

S

43358

Australia

 

≤0.25

≤0.25

≤0.25

S

S

43854

Australia

 

≤0.25

≤0.25

≤0.25

S

S

A1

Norway

 

S

≤0.25

≤0.25

S

S

A2

Norway

 

S

≤0.25

≤0.25

S

S

A3

Norway

 

S

≤0.25

≤0.25

S

S

A4

Norway

 

S

≤0.25

≤0.25

S

S

A7

Norway

 

S

≤0.25

≤0.25

S

S

A13

Norway

 

S

≤0.25

≤0.25

S

S

A15

Norway

 

S

≤0.25

≤0.25

S

S

A16

Norway

 

S

≤0.25

≤0.25

S

S

2890369

England

 

1

≤0.25

0.5

S

S

2980639

England

 

1

≤0.25

0.5

S

S

10924

Sweden

KPC

4

≤0.25

0.5

S

S

3040820

England

pAmpC

≤0.06

0.5

≤0.25

S

S

270902

England

 

0.125

0.5

≤0.25

S

S

44271

Australia

 

≤0.25

0.5

0.5

S

S

K23

Australia

IMP - 4

0.5

2

0.5

S

S

500638

Sweden

pAmpC

≤0.25

4

2

NS

NS

KS1

Sri Lanka

OXA-181

1

4

2

NS

S

374

Sweden

VIM

>32

8

32

NS

NS

K16

Australia

IMP - 4

2

16

2

NS

S

ATCC BAA 1705

USA

KPC

8

16

8

NS

NS

200822

Sweden

KPC

8

16

8

NS

NS

A20

Norway

NDM-1

R

16

16

NS

NS

70708

Sweden

KPC

16

32

32

NS

NS

71076

Sweden

KPC

≥32

32

32

NS

NS

3000770

England

NDM-1

>32

32

8

NS

NS

N17

Sweden

NDM-1

≥32

32

32

NS

NS

K2

Australia

OXA-181

64

32

32

NS

NS

2880654

England

KPC

4

64

32

NS

NS

194

Sweden

VIM

≥32

64

16

NS

NS

KS17

Sri Lanka

OXA-181

≥32

64

64

NS

NS

K1

Australia

OXA-181

64

64

32

NS

NS

KS2

Sri Lanka

OXA-181

≥32

128

16

NS

NS

KS23

Sri Lanka

OXA-181

≥32

128

64

NS

NS

3080800

England

KPC

>32

256

32

NS

NS

K8

Australia

NDM-1

>256

>256

>256

NS

NS

K14

Australia

KPC

256

>256

>256

NS

NS

  1. MICFAST: FAST method MIC.
  2. MICBMD: broth microdilution MIC.
  3. S: Susceptible to meropenem, MIC ≤ 2 mg/L.
  4. NS: Non-susceptible to meropenem, MIC > 2 mg/L.
  5. 48 isolates were exposed to therapeutic grade meropenem and subjected to FAST in technical triplicate, with the MICFAST and MICBMD values reported as the mode of replicates. Interpretation was according to EUCAST criteria: (S = MIC ≤2 mg/L; NS = MIC >2 mg/L).