Figure 6 | Scientific Reports

Figure 6

From: A-to-I editing in human miRNAs is enriched in seed sequence, influenced by sequence contexts and significantly hypoedited in glioblastoma multiforme

Figure 6

MiRnome wide hypo-editing and ADAR2 downregulation in glioblastoma multiforme. (A) Small RNA sequencing revealed miRnome-wide significant (two-tailed Wilcoxon test) hypoediting in GBM compared to FC (p = 0.009) and CC (p = 0.004) samples. (B) Real time PCR validation of ADAR2 in GBM samples compared to FC and CC samples. Y-axis shows ΔCt values of ADAR2 in five FC, five CC and five GBM samples and B2M expression was used for normalization. ADAR2 is significantly (two-tailed t-test) downregulated in GBM compared to FC (p = 0.002) and CC (p = 0.009) samples.

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