Figure 5
From: Growth hormone reverses dyslipidemia in adult offspring after maternal undernutrition
ChIP-PCR analysis of H3 acetylation at the promoter of AMPK-α1 with antibody to histone H3. Acetylation of histone H3 at neonatal (A) adolescent (B) and adult (C) periods. Quantification was performed using real-time PCR with primers specific to the proposed AMPK-α1 element sites (A1: −449 to −640; A2: −887 to −1099; A3: −1330 to −1526). Statistical differences between the groups are given as follows: **p < 0.01: AGA vs SGA; & p < 0.05: AGA + NS vs SGA + NS; # p < 0.05: SGA + NS vs SGA + rhGH. n = 6 per experimental group.
