Table 1 Association signals for CAD within 200 kb of genes reported for coxib/gene product interactions.

From: A genomic exploration identifies mechanisms that may explain adverse cardiovascular effects of COX-2 inhibitors

Gene

Lead SNP

CAD risk allele

Frequency risk allele

OR risk allele

P-value

P-value combined analysis

Relationship of coxib to gene/gene product*

Regulatory effect (Histone marks)

BCAR1

rs4888383

T

0.57

1.05

7.99*10−08

2.98*10−08

inhibition

Promoter/Enhancer

MMP9

rs7270354

A

0.15

1.06

6.75*10−08

3.34*10−08

decreased expression

Promoter/Enhancer

VEGFA

rs6905288

A

0.60

1.04

7.44*10−07

8.86*10−07

decreased expression

Enhancer

CACNA1E

rs556321

C

0.16

1.05

8.26*10−06

8.85*10−06

inhibition

Promoter/Enhancer

  1. For each gene, the lead SNP is shown. The regulatory effects were annotated using Haploreg25.
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