Figure 4
Overall behavioural changes are structured along specific dimensions. (A) Main factors (and respective loadings) obtained following factor analysis of behavioural variables (v1-v26) measured in the open field (OF) and elevated plus maze (EPM). (B,C) Distribution of the behavioural variables (1–26) in bi-dimensional spatial projections of the first three dimensions (Factors 1, 2 and 3). Coloured ellipses represent different variable groupings (see text for details). (D) Spatial distribution of individuals of the different experimental groups in the tridimensional space defined by Factors 1, 2 and 3. Mouse saline group, n = 25; TgWT group, n = 15; TgAaaH2KO group, n = 25. (E) Factor scores for individual animals in the three experimental groups calculated from loadings derived from factor analysis. Although no differences were detected between TgWT and TgAaaH2KO-infected animals, both infected groups showed significantly different loadings, relative to controls, for Factor 2, which represents the structure of risk/unconditioned fear behaviour. *p < 0.05. The data are presented as the mean ± SEM.
