Table 2 Body weight and organ mass in sedentary or exercised or NMN treated offspring of obese mothers that consumed chow or HFD post-weaning.

From: Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: comparison with exercise

	CCS	CHS	HCS	HCX	HCN	HHS	HHX	HHN
Final BW (g)	18.1 ± 0.2	20.9 ± 0.1	19.5 ± 0.3	18.5 ± 0.3^X	18.7 ± 0.2^	28.04 ± 1.2	24.3 ± 0.9^XX	24.8 ± 0.7^
Liver (mg)	765 ± 14	693 ± 13	779 ± 43	758 ± 23	811 ± 18	852 ± 27	779 ± 26	763 ± 22
Muscle (mg)
Quad	236 ± 10	256 ± 11	247 ± 10	254 ± 12	272 ± 6	295 ± 8	303 ± 5	304 ± 7
AT	82 ± 4	88 ± 3	87 ± 3	86 ± 3.21	87 ± 3	98 ± 5	110 ± 4	100 ± 5
Soleus	12.4 ± 0.7	15.9 ± 0.7	15.1 ± 0.7	15.0 ± 0.5	16.3 ± 1.1	19.6 ± 0.6	20.2 ± 0.5	19.2 ± 0.7
WAT (mg)
Gonadal	141 ± 8	601 ± 89	231 ± 22	231 ± 14	202 ± 15	1348 ± 16	946 ± 149^X	923 ± 92^
Inguinal	165 ± 11	463 ± 57	207 ± 13	232 ± 14	196 ± 5	823 ± 108	512 ± 66^XXX	532 ± 58^^
RP	26.1 ± 2.3	143.0 ± 25.2	44.5 ± 4.2	43.1 ± 2.4	40.5 ± 2.2	347.5 ± 33.5	252.0 ± 38.2^XX	220.5 ± 22.1^^^
Plasma Insulin (ng/mL)	0.085 ± 0.020	0.154 ± 0.016	0.166 ± 0.020	0.224 ± 0.037	0.317 ± 0.030^	0.420 ± 0.0.038	0.469 ± 0.033	0.588 ± 0.064^^
Plasma Triglycerides (mg/mL)	2.82 ± 0.24	3.21 ± 0.16	2.94 ± 0.11	3.38 ± 0.23	2.31 ± 0.41	3.62 ± 0.22	3.83 ± 0.24	3.14 ± 0.26
Main effects of the ANOVA analysis of HC, HCX, HCN, HH, HHX, HHN offspring
		Intervention			Post Weaning Diet		Interaction
Kill BW (g)		F(2,64) = 6.7, P < 0.01			F(1,64) = 135.5, P < 0.001		ns
Liver (mg)		ns			ns		ns
Muscle (mg)	Quad	ns			F(1,63) = 39.4, P < 0.001		ns
	AT	ns			F(1,64) = 26.1, P < 0.001		ns
	Soleus	ns			F(1,62) = 49.5, p < 0.001		ns
WAT (mg)	Gonadal	F(1,65) = 3.1, P < 0.05			F(1,65) = 110.7, P < 0.001		ns
	Inguinal	F(1,62) = 3.7, P < 0.05			F(1,62) = 74.9, P < 0.001		F(1,62) = 4.3, P < 0.05
	RP	F(1,63) = 4.6, P < 0.05			F(1,63) = 157.3, P < 0.001		F(1,63) = 4.1, P < 0.05
Plasma Insulin (ng/mL)		F(1,49) = 7.2, P < 0.01			F(1,49) = 54.7, P < 0.001		ns
Plasma Triglycerides (mg/mL)		F(1,50) = 5.9, P < 0.01			F(1,50) = 9.6, P < 0.01		ns

Data are shown as mean ± SEM, n = 11–12 per group. The first letter indicates maternal diet, chow (C) or HFD (H); second letter indicates post-weaning diet (C or H); the third letter represents intervention; sedentary (S), exercise (X) or NMN (N). To explore the impact of post-weaning diet and intervention (exercise and NMN) on body weight and tissue phenotypes, the offspring groups HCS, HCX, HCN and HHS, HHX, HHN were analysed by a two-way mixed ANOVA presented upper section of the table. Offspring from lean mothers (CCS & CHS) are shown for comparison. Abbreviations: BW, body weight; WAT, white adipose tissue. Overall effects are presented in the bottom section of the table. The significant effects are:
^XP < 0.05, ^XXP < 0.01, ^XXXP < 0.001 simple main effect of exercise.
^{^}P < 0.05, ^{^^}P < 0.01, ^{^^^}P < 0.001 simple main effect of NMN.

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Table 2 Body weight and organ mass in sedentary or exercised or NMN treated offspring of obese mothers that consumed chow or HFD post-weaning.

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