Table 1 HIV-1 infection rate (plasma titre >40 copies/mL) in humanized mice with <10% and >10% circulating hCD45+ cells 5 weeks after intravaginal challenge with low (103 TCID50 HIV-1) or high (105 TCID50 HIV-1) dose of viral inoculum.

From: Frequency of Human CD45+ Target Cells is a Key Determinant of Intravaginal HIV-1 Infection in Humanized Mice

 

Low Dose (103) Challenge

High Dose (105) Challenge

<10% Circulating hCD45+ Cells

1/6 16.7%

8/12 66.7%

>10% Circulating hCD45+ Cells

4/5 80.0%

10/12 83.3%

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