Figure 10 | Scientific Reports

Figure 10

From: The selective reversible FAAH inhibitor, SSR411298, restores the development of maladaptive behaviors to acute and chronic stress in rodents

Figure 10

Effects of SSR411298 in several models of anxiety involving prior stress exposure, including (A) social defeat induced anxiogenic-like behavior in mice in the elevated plus-maze test. *P < 0.05, **P < 0.01 (vs stressed vehicle) and +P<0.05, ++P < 0.01 (vs non-stressed vehicle). N = 8–13 mice per group; (B) ultrasonic distress vocalizations emitted during three minutes by 7-day-old rat pups separated from their mother and littermates. *P < 0.05, **P < 0.01 and ***P < 0.001. N = 7–10 rat pups/group; (C) short-term memory impairment induced by inescapable stress in an object recognition task mice. **P < 0.01, ***P < 0.001, new vs familiar object. N = 10 mice per group. Data represent mean+SEM.

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