Table 2 Rimonabant-precipitated withdrawal signs in mice treated with SSR411298 or Δ9-THC.

From: The selective reversible FAAH inhibitor, SSR411298, restores the development of maladaptive behaviors to acute and chronic stress in rodents

 

Control

SSR411298 (20 mg/kg, i.p.)

Δ9-THC (10 mg/kg, s.c.)

Paw tremor

7,79 ± 2,28

12,20 ± 2,62

91,31 ± 11,58**

Stretch

2,64 ± 1,99

1 ± 0,37

24,31 ± 4,31**

Ptosis

0 ± 0

0 ± 0

3,85 ± 1,53*

Chew

0,79 ± 0,30

1,20 ± 0,38

4 ± 0,90**

Hunched posture

0,57 ± 0,44

0,33 ± 0,16

7,15 ± 2,09**

Scratch

339,21 ± 49,13

288,27 ± 42,59

23,15 ± 4,77**

Lick

44,57 ± 4,58

55,47 ± 4,07

30,46 ± 3,91

Grooming

13,79 ± 1,62

13,27 ± 2,03

5,23 ± 1,75**

  1. Treatment schedule: 2 injections/day/4 days. On day 5, the drugs were administered 4 hours after the last injection of rimonabant (10 mg/kg i.p.). Data represent mean ± SEM. *P < 0.05, **P < 0.01. N = 13 to 14.
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