Figure 3
Human validation of the histologic hypothesis as a prognostic biomarker. (A) Example of manual scoring of SI from observers (Obs) 1 and 2. Patient 1 was deceased and had a low SI score; patient 2 was living and had a high SI score. (B) Kaplan Meier survival analysis for the full TMA dataset. Cases were divided into high SI (red; >median SI score; n = 195) and low SI (black; ≤median SI score; n = 229) groups. Survival was significantly better for the high SI group in comparison to the low group (median survival of 65.0 vs 33.3 months, respectively; log rank p-value = 4.6 × 10−5). The results for observers 1 (this Figure) and 2 (see Supplementary Figure 2) were similar.
