Table 1 Dose response data of modulators. Data are presented as mean ± SD, (n = 3).

From: Natural polyphenols as sirtuin 6 modulators

 

Compound

IC50 value (µM)

4

(−)-Catechin gallate

2.5 ± 0.03

5

(−)-Gallocatechin gallate

5.4 ± 0.04

 

Compound

EC 50 value ( µ M)

Maximal activation (fold)

13

Luteolin14

270 ± 25

6.1

14

Kaempferol

n.d

3.0

15

Quercetin14

990 ± 250

10

16

Myricetin

404 ± 20

7.7

17

Cyanidin

460 ± 20

55

18

Delphinidin

760 ± 200

6.3

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