Figure 4
From: Protein-bound NAD(P)H Lifetime is Sensitive to Multiple Fates of Glucose Carbon
Metabolic diagram of enzyme inhibition with DCA and FX11 treatment. Summary of cellular metabolic pathways investigated using metabolic inhibitors DCA and FX11 (diamonds). Red arrows indicate a decrease in activity, while green arrows indicate an increase, and black arrows indicate no change. Enzymes are shown in boxes, enzyme-containing pathways such as glycolysis and oxidative phosphorylation are circled, while enzyme products and substrates are unboxed. Both FX11 and DCA result in an overall increase in oxygen consumption, but by acting on different enzymes. DCA inhibits PDK to increase the activity of PDH, allowing pyruvate to enter the mitochondria and fuel oxidative phosphorylation. FX11 has a similar effect, but acts by inhibiting the ability of LDH to convert pyruvate into lactate.
