Figure 6 | Scientific Reports

Figure 6

From: Aloperine Protects Mice against Bleomycin-induced Pulmonary Fibrosis by Attenuating Fibroblast Proliferation and Differentiation

Figure 6

The impact of aloperine on TGF-β-stimulated Smad signaling in mouse lung fibroblasts. (A) Administration of aloperine attenuated TGF-β-induced Smad signaling. Left panel: representative western blot results for p-Smad2, p-Smad3, and Smad2/3 at 3 h after TGF-β stimulation. Right panel: bar graphic figure showing the data with 3 replications. (B) Aloperine treatment did not affect TGF-β-induced MAPK signaling. Left panel: representative western blot results for p-P38/P38, p-Jnk/Jnk, p-Erk1/2/Erk1/2 at 3 hafter TGF-β stimulation. Right panel: bar graphic figure showing the data with 3 replications. Statistical analysis was performed by Two-way ANOVA with Newman-Keuls post-hoc test. **p < 0.01; ***p < 0.001.

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