Figure 4
From: Locus Coeruleus as a vigilance centre for active inspiration and expiration in rats
Acute inhibition of A6 neurons and effect on the inspiratory and ventilatory responses to systemic hypoxic hypoxia of conscious adult rats. (A) Raw and integrated (∫) records of DiaEMG activity from a rat in which the LC was transduced with PRSx8-AlstR-GFP-LVV, illustrating the changes in inspiration and in the number of sighs (red lines) induced by systemic hypoxic hypoxia (7% O2) before and after Alst application into lateral ventricle. (B) Magnification of baseline and reflex inspiratory and ventilatory (barometric respiratory movements) responses from the same rat before and after Alst application. Note the absence of changes in the hypoxia-induced inspiratory and ventilatory responses, but the significant reduction in the number of sighs, after acute inhibition of A6 neurons.
