Figure 6
Effects of IKr inhibition on heart rate and QT-interval. (a) Example magnetometer signals recorded before and after administration of 0.06 μM E-4031. Traces are the averages of approximately 10 heartbeats. (b) Heart rate in beats per minute: bpm = 60/RR-interval [s]. Points are mean values averaged over 5 animals. Error bars represent the standard error of the mean. (c) QT-interval corrected for heart rate (Bazett correction35). In (b and c), heart rate and QT-intervals are measured before (t = 0 data points) and 5, 10, 15, and 20 minutes after administration of the drug.
