Table 1 Administered doses to animals in the different groups.

From: A 14-day repeat dose oral gavage range-finding study of a first-in-class CDI investigational antibiotic, in rats

Group

No. Animals/Group (M/F)

Target Dose Level (mg/kg/day)

Dose Concentrationa (mg/mL)

Main Test

1

3/3

Vehicle Controlb

0

2

3/3

50

5

3

3/3

500

50

4

3/3

1500

150

Toxicokinetic Satellite

5

3/3

Vehicle Controlb

0

6

3/3

50

5

7

3/3

500

50

8

3/3

1500

150

  1. aAppropriate concentrations of Ramizol in vehicle to achieve the target dose level. bSodium phosphate buffer (0.1 M, pH 7.4). Dose volume is 10 mL/kg/day.