Table 1 Specific baseline parameters on ALSFRS-r progression.

From: A ferroptosis–based panel of prognostic biomarkers for Amyotrophic Lateral Sclerosis

Factors at baseline

Unadjusted

Adjusted*

Coefficient β ± SE

P-value

Coefficient β ± SE

P-value

NfLa

−0.05 (0.005)

<0.001

−0.03 (0.005)

<0.001

pNfHa

−0.01 (0.001)

<0.001

−0.006 (0.001)

<0.001

4-HNEa

−0.16 (0.01)

<0.001

−0.15 (0.01)

<0.001

8-OHdG

−0.02 (0.004)

<0.001

−0.02 (0.003)

<0.001

Ferritina

−0.006 (0.002)

0.005

−0.006 (0.002)

0.001

Hepcidinc

−0.02 (0.01)

0.083

−0.01 (0.01)

0.27

Transferrinb

−0.0001 (0.003)

0.97

−0.0001 (0.003)

0.96

IL-6

0.001 (0.002)

0.65

−0.002 (0.002)

0.46

Isoprostane

0.12 (0.07)

0.073

0.07 (0.06)

0.26

  1. Specific parameters were evaluated on an allocated treatment group. Linear mixed models with random intercept before and after adjustment to baseline characteristics associate with ALSFRS-r progression (p < 0.10 for their interaction with time in multivariate analysis). *Adjusted on treatment and pre-specified baseline factors with their interactions to time (BMI, MMT, SVC, sodium and time since the onset of clinical signs). a–cA coefficient corresponding to the effects of a respective 10, 1000 and 10000 point increase.
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