Table 1 Automatically assessed model parameters for experimental datasets given in Fig. 4.
From: Quantitative dynamics of reversible platelet aggregation: mathematical modelling and experiments
Parameter | 2.5 µM ADP | 5 µM ADP | 10 µM ADP | 20 µM ADP | 2.5 µM ADP | 5 µM ADP | 10 µM ADP | 20 µM ADP | 40 µM ADP |
|---|---|---|---|---|---|---|---|---|---|
single | single | single | single | dual | dual | dual | dual | dual | |
probability of a platelet attachment to an existing aggregate, k1, 1/([plt]*s) | 8.6*10−4 | 6.8*10−4 | 5.2*10−4 | 4.3*10−4 | 4.8*10−6 | 4.6*10−6 | 1.3*10−5 | 1.8*10−5 | 1*10−5 |
probability of single platelet detachment from an aggregate, k−1, 1/s | 1.0*10−9 | 4.0*10−16 | 3.5*10−15 | 1.0*10−4 | 3.2 | 1.22 | 1.15 | 0.39 | 0.2 |
probability of one aggregate formation from two existing, k−2, 1/([plt]*s) | 6.7*10−4 | 3.8*10−4 | 2.3*10−4 | 7.6*10−7 | 5.7*10−7 | 2.5*10−7 | 8.7*10−8 | 7.1*10−8 | 6.5*10−8 |
probability of an aggregate fragmenting into two, k3, 1/s | 0.07 | 0.03 | 0.02 | 0.005 | 0.03 | 0.017 | 0.009 | 0.007 | 0.0035 |
probability of a new aggregate formation, k2, 1/([plt]*s) | 3.8*10−5 | 3.9*10−5 | 5.1*10−5 | 2.7*10−4 | 2.5*10−10 | 1.0*10−9 | 2.5*10−9 | 1.7*10−8 | 3*10−8 |
initial concentration of platelets, p0, [plt] | 100 | 100 | 100 | 100 | 742779 | 433994 | 125561 | 54038 | 35000 |
