Table 1 Identified Raman peaks that are altered due to global DNA methylation in mESCs and human colon cancer cells.

From: Non-invasive detection of DNA methylation states in carcinoma and pluripotent stem cells using Raman microspectroscopy and imaging

Raman Shift (cm−1)

Assignment

↑↓ relative Raman intensity for high-methylated cells

786

5-Methylcytosine52, Cytosine, Thymine, Phosphate backbone of DNA/RNA39,47,48,49

↑

815–830

Phosphate backbone of DNA/RNA54

↓

1257

Cytosine, Adenine38,41

↑

1317–1323

Guanine41,47

↑

1335

CH2CH3 wagging37

↑

1342

Guanine47

↑

1379/1386

CH339,53

↑

1579

Pyrimidine ring39

↑

1605–1610

Cytosine41

↑

1662

DNA58,59

↑

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