Figure 2
From: Heterozygous mutations in valosin-containing protein (VCP) and resistance to VCP inhibitors
The Gene Set Enrichment Analysis indicates unfolded protein response gene set is positively enriched in CB-5083-treated cells. The complete results of GSEA analysis are available at the following link: https://osf.io/uzdbw/. GSEA analysis showing the gene set enrichment analyses in parental (A) and resistant (B) cell line with CB-5083 treatment. Enrichment plots depicting the enrichment pattern in the unfolded protein response (UPR) pathway in parental (C) and resistant (D) cells with CB-5083 treatment. Enrichment plots depicting the enrichment pattern in the myc targets in parental (E) and resistant (F) cells with CB-5083 treatment.
