Figure 2
From: Epitope Mapping by NMR of a Novel Anti-Aβ Antibody (STAB-MAb)
EM analysis of the effect of STAB-MAb in the formation and disassembly of Aβ(1–42) structures in vitro. Electron micrographs of (A) a freshly resuspended solution of 50 µM Aβ(1–42) in 10 mM PBS, (B) fibrillary assemblies in a 50 µM Aβ(1–42) solution following a 96-hour incubation period at 37 °C, (C) a 50 µM Aβ(1–42) solution following a 96-hour incubation period at 37 °C in presence of 25 µM STAB-MAb, (D) a 50 µM Aβ(1–42) solution following a 96-hour incubation period at 37 °C in presence of 50 µM STAB-MAb, and (E) 25 µM Aβ(1–42) solution following a 96-hour incubation period at 37 °C, succeeded by a short 24-hour incubation with 25 µM STAB-MAb at the same temperature.
