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Figure 1

From: Human thioredoxin, a damage-associated molecular pattern and Malassezia-crossreactive autoallergen, modulates immune responses via the C-type lectin receptors Dectin-1 and Dectin-2

Figure 1

Cytokine response to fungal glycans, the fungal allergen Mala s13, and its human homologue hTrx. Secretion of IL-1β (A) and IL-23 (C) was measured in moDC or M1-macrophage cell culture supernatants by ELISA 16–18 h after stimulation as depicted (moDC n = 25; M1-macrophages n = 6). IL-1β (B) and IL-23 (D) release by moDC in response to the Mala s13, hTrx and the respective LPS contamination levels in the assay, 5 pg/ml and 25 pg/ml (n = 7). (E) Cytokine response to Zymosan depleted, Mala s13, and hTrx compared to further recombinant microbial antigens (Mala s6, Mala s11, FBP1) and a truncated form of hTrx (Trx80) (n = 6).

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