Table 4 Comparison of CYP2B11 haplotype frequencies in Greyhound, Beagle and mixed-breed dogs.

From: Pharmacogenomics of poor drug metabolism in Greyhounds: Cytochrome P450 (CYP) 2B11 genetic variation, breed distribution, and functional characterization

Breed

N dogs

Number of dogs with each CYP2B11 diplotype

Haplotype frequency (%)

H1/H1

H1/H2

H2/H2

H1/H3

H2/H3

H3/H3

H2

H3

Beagle

50

30

15

5

0

0

0

25

0

Mixed-breed

153

95

44

9

3

2

0

21

2

Greyhound (NGA)

180

56

54

12

39

14

5

26

18

Greyhound (AKC)

61

14

0

0

22

0

25

0

59

  1. DNA samples were genotyped by allelic discrimination assay for haplotype-specific polymorphisms, including c.2137 TG/CA (CYP2B11-H2) and c.1952 C/T (CYP2B11-H3). Shown are the numbers of dogs with each diplotype and the derived haplotype frequencies. Greyhounds were divided into two groups based on whether they were identified by their owners as dogs registered with the National Greyhound Association (NGA) bred for racing or dogs registered with the American Kennel Club (AKC) bred for other purposes.
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