Figure 2
From: The anti-tumoral potential of the saporin-based uPAR-targeting chimera ATF-SAP
Cytotoxic activity of ATF-SAP on bladder and breast cancer cells. ATF-SAP activity and target specificity were evaluated on RT4, RT112, 5637, HT1376 and ECV304 bladder cancer cell lines (A) and on MDA-MB-468, SUM149, SUM159, BT549 TNBC and HER2+ SKBR3 breast cancer cell lines. (B) Cells were incubated for 72 h with scalar logarithmic concentrations of the toxin and cell viability was analyzed by MTT assay. The untargeted seed SAP and the catalytically inactive mutant ATF-SAP KQ were used as controls. The IC50 from three different experiments is reported as mean ± SE.
