Table 3 Node divergence estimates for the Lisboa3 and Q1 clades along with some of its sub-branches, including drug resistance associated with node and respective mutational profiles.
Clade/Node | No. of Isolates Detected | Node Age Mean | 95% HPD Interval | Intra-clade Median SNP Distance | Resistance Associated | Node Mutational Profile |
|---|---|---|---|---|---|---|
Lisboa3 | 72 | 1950.0 | 1940.0–1964.5 | 23 | ||
MDR1 | 24 | 1974.5 | 1956.1–1990.0 | 11 | MDR/XDR | inhA:C-15T/S94A; rpoB:S450L; rpsL:K43R |
MDR2 | 25 | 1972.9 | 1947.6–1993.6 | 10 | MDR/XDR | inhA:C-15T/S94A; rpoB:S450L; rpsL:K43R |
Lisboa3-A | 7 | 1981.8 | 1968.7–1991.8 | 6 | MDR | inhA:C-15T/S94A; rpoB:D435V; rpsL:K43R |
XDR1 | 17 | 1987.8 | 1978.1–1995.8 | 8 | XDR | gyrA:S91P; eis:G-10A |
XDR2 | 21 | 1990.4 | 1979.1–2000.3 | 9 | XDR | gyrA:D94G; eis:G-10A |
Q1 | 35 | 1968.1 | 1942.1–1989.3 | 10 | ||
MDR | 34 | 1976.5 | 1954.6–1994.9 | 10 | MDR/XDR | inhA:C-15T/I194T; rpoB:S450L; gidB:A80P |
XDR | 15 | 1994.3 | 1983.5–2003.0 | 5 | XDR | gyrA:D94G; rrs:A1401G |
