Table 1 Results from vaccinations of two varieties of commercial chickens with varying doses of inactivated vaccines against HPAI.

Vaccines	Chicken species (age)	Antigen Dose^a	Survival(%) (MDT)^b	Morbidity	Peak shedding (3 dpi)^c		HI titer(log₂)^d		PD₅₀
Vaccines	Chicken species (age)	Antigen Dose^a	Survival(%) (MDT)^b	Morbidity	OP	CL	Pre-challenge (Homo)	Post-challenge (Homo)	PD₅₀
rgKA435/2.3.2.1c	Layer chickens (35w)	1	100		1/10 (0.1)	0/10 (−)	10/10 (7.5)	10/10 (8.7)	100
		1/10	80 (7.5)		6/10 (1.2)	2/10 (0.3)	10/10 (6.0)	10/10 (7.6)
		1/100	70 (5.7)	Mild depression, green diarrhea	6/9 (1.3)	2/9 (0.3)	2/10 (3.3)	5/10 (7.1)
		Sham	0 (3.1)	Lethargy, mortality	1/1 (3)	1/1 (3.3)	0/10 (−)	NT
	Breeder chickens (35w)	1	100		0/8 (−)	0/8 (−)	8/8 (7.2)	8/8 (8.5)	63
		1/10	100		2/8 (0.4)	0/8 (−)	8/8 (6.5)	8/8 (7.6)
		1/100	37.5 (4.6)	Mild depression, green diarrhea, mortality	8/8 (2.1)	7/8 (2.2)	5/8 (2.4)	3/3 (7.3)
		Sham	0 (3)	Lethargy, mortality	NT	NT	0/8 (−)	NT
rgES2/ 2.3.4.4c	Layer chickens (35w)	1	100		0/10 (−)	0/10 (−)	10/10 (8.5)	10/10 (9.6)	350
		1/10	100		1/10 (0.1)	0/10 (−)	10/10 (6.9)	10/10 (8.0)
		1/100	100	Mild depression	0/10 (−)	0/10 (−)	7/10 (5.0)	10/10 (7.4)
		Sham	0 (3.8)	Lethargy, mortality	7/7 (4.3)	6/7 (2.2)	0/10 (−)	NT
	Breeder chickens (35w)	1	100		0/8 (−)	0/8 (−)	8/8 (7.5)	8/8 (8.3)	215
		1/10	100		2/8 (0.7)	0/8 (−)	8/8 (7.1)	8/8 (8.0)
		1/100	75 (6.5)	Depression, green diarrhea, mortality	2/8 (0.7)	1/8 (0.3)	8/8 (4.8)	5/5 (6.6)
		Sham	0 (2.9)	Lethargy, mortality	NT	NT	0/8 (−)	NT

^aOne dose (1) contained 512 HAU (hemagglutination units).
^bMDT = mean death time (days).
^cNo. virus positive/total in group (mean shed-virus titer).
^dNo. serology positive/total surviving in group (mean HI titer).
No. of commercial chicken: 10 layer chickens per group; 8 breeder chickens per group
Abbreviations: EID₅₀, 50% egg infectious dose; HA, hemagglutination activity; NT, not tested; dpi, days post-infection; OP, oropharyngeal; CL, cloacal; HI, hemagglutination inhibition; PD₅₀, 50% protective dose.

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