Figure 3

Comparison of median number of influenza-specific infection-elicited and vaccine-elicited cytokine-producing CD4⁺ and CD8⁺ T-cells in SOT recipients. SOT: Solid organ transplant; IFN-γ: interferon-γ; TNF-α: tumor-necrosis factor-α; IL: interleukin. Results were expressed as number of vaccine-elicited cytokine-producing CD4⁺ cells/10⁶ CD4⁺ T-cells and number of cytokine-producing CD8⁺ cells/10⁶ CD8⁺ T-cells. For data presentation, cell frequencies labelled as TNFα⁺, IFNγ⁺, IL2⁺ or IL4⁺ were cells producing the given cytokine, regardless of the production of other cytokines. The boxes represents the median value. Pre-vaccination frequencies were subtracted from post-vaccination frequencies to highlight vaccine-elicited responses, whereas frequencies at influenza diagnosis were subtracted from frequencies at Day 28 to highlight infection-elicited responses.