Figure 6
From: The operational model of allosteric modulation of pharmacological agonism
Effects of an allosteric agonist that neither affects affinity (α = 1) nor functional efficacy (β = 1) of an orthosteric agonist. Effects of an allosteric agonist where efficacy is smaller (left) or greater (right) than the efficacy of the orthosteric agonist on the functional response to an orthosteric agonist (top); observed half-efficient concentration EC'50 and observed maximal response E'MAX (middle); and dose ratio of half-efficient concentrations (bottom). EMAX = 1, α = 1, β = 1, operational efficacies τA and τB of the orthosteric and allosteric agonist, respectively, are indicated within the plots.
